This case study examines the intricate relationship between organizational culture and change management at the Ghana Institute of Management and Public Administration (GIMPA). With the rapid evolution of the educational landscape, GIMPA has undertaken significant initiatives to adapt to new demands and challenges. This research employs qualitative methods, including interviews and focus group discussions, to explore how GIMPA's unique cultural attributes influence its change management strategies. Findings reveal that a strong commitment to collaborative leadership, inclusivity, and continuous improvement fosters a supportive environment for change initiatives. The study also highlights the challenges posed by entrenched cultural norms and resistance to change. By identifying key cultural factors that facilitate or hinder effective change management, this research provides valuable insights for organizational leaders and practitioners in higher education and other sectors. Ultimately, this case study underscores the importance of aligning change strategies with organizational culture to enhance the success of transformation efforts.